It is important, though, to limit your usage of this product to nighttime only, just as it says on the instructions (you're a rule follower, right?). "Retinol is the most effective over-the-counter wrinkle fighter and RoC is a pioneer in the use of this ingredient," Underwood says. After just two weeks of twice daily use I noticed my smile lines and acne-related dark spots began to disappear. My face is definitely glowing whenever I apply this face cream. WHAT'S YOUR SKIN AGE? The doctors I c...